Before 1516 the confraternity of Saint Reinhold in Gdańsk commissioned a retable for the Saint Reinhold Chapel of the Saint Mary's Church in the city. The outer wings of the polyptych were painted in the workshop of Joos van Cleve, who depicted himself as Saint Reinhold.
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The polyptych was shipped to Gdańsk in 1516 and today is on display in the Gallery of Medieval Art of the National Museum in Warsaw (oak, central panel 194 × 158 cm (76.4 × 62.2 in), each wing 194 × 75 cm (76.4 × 29.5 in)). It is the first confirmed work commissioned by patrons from territories of today's Poland.

The second could be Triptych with the Adoration of the Magi with a monarch in a chain of the Order of the Golden Fleece in the Gemäldegalerie, Berlin (oak, central panel 72 × 52 cm (28.3 × 20.5 in), each wing 69 × 22 cm (27.2 × 8.7 in)). It was acquired from the Reimer Collection in Berlin in 1843. Possibly commissioned by Sigismund I of Poland.
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The outer parts of the wings were painted en grisaille with effigies of Saints Christopher and Sebastian, which may indicate the donor, his patron saints, however among recipients of the Order of the Golden Fleece between 1451 and 1531 there were no Sebastian and only one Christopher - Christopher, Margrave of Baden-Hachberg (1453-1527). Although the latter was portraited in the similar headdress (crinale), he was not a king to depict himself as one of the Magi, and his facial features are completely different. Also other garments are very close to those from the known effigies of the Polish monarch - eg. Communion of Sigismund I, a leaf from the Prayer Book of Sigismund I the Old by Stanisław Samostrzelnik from 1524 in the British Library. The king of Poland was awarded the Order of the Golden Fleece in 1519 at the age of 52.

The sources on artistic contacts of the Polish court at that time with the Netherlands are very scarce. Among commissions confirmed in preserved inventories and accounts the are the following.

In 1526 queen Bona Sforza commissioned in Antwerp through Seweryn Boner, 16 tapestries "de lana cum figuris et imaginibus" of 200 flemish square inches in its entity. They were transported to Kraków via Frankfurt upon Main, Nuremberg and Wrocław.

In 1533 king Sigismund I commissioned through Boner and Mauritius Hernyck in Antwerp 60 tapestries with coat of arms od Poland, Lithuania and Duchy of Milan among which 20 bigger with green and blue background, 26 tapestries without coat of arms and 6 tapestries with figural scenes. The commission cost was 1170 florins and tapestries were transported to Kraków via Nuremberg, Leipzig and Wrocław.

In 1536 the king acquired 7 paintings in Flanders to adorn the apartments of prince Sigismund Augustus at the Wawel castle for 35 florins ("pro septem imaginibus Flandrensibus pictis").

The subtle marble bust of Queen Barbara Zapolya from Olesko Castle in the style of Netherlandish renaissance was probably part of a larger commission made by Sigismund I around 1520.

​oil on panel, ca. 1535, 33.6 × 25.2 cm (13.2 × 9.9 in), inventory number Wil.1591, Museum of King John III's Palace at Wilanów

​The painting represents one of several versions of ''Madonna of the Cherries'' created by Giovanni Pietro Rizzoli, called Giampietrino in about 1508-1510 when he was working alongside Leonardo da Vinci. The Giampietrino's painting is possibly a reproduction of a Madonna painted by Leonardo for Francis I of France. The latter work was probably a painting that influenced Joos van Cleve who was frequently employed by French court. The painting by Giampietrino from doctor Karl Lanz's collection is a direct link to the lost da Vinci's original. The composition enjoyed great success in the early decades of the 16th century and some twenty three versions attributed to Joos van Cleve's workshop have been identified. 
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Similar painting is in the Arnold and Seena Davis Collection. The work was acquired by Stanisław Kostka Potocki for his collection in the Wilanów Palace in Warsaw.

The first wooden manor on the site was constructed for Dukes of Masovia in the 15th century. It was later owned from 1516 by Anna Radziwiłł, Duchess regent of Masovia and Queen Bona Sforza after 1546 for whom an Italian style Renaissance garden was created. The new lavish wooden manor in mannerist style was built in 1570s for Anna Jagiellon. It was here that the premiere of blank-verse tragedy The Dismissal of the Greek Envoys by Jan Kochanowski took place on January 12, 1578. Sigismund III Vasa resided in the manor during the summer. Between 1602 and 1603, according to the Royal accounting books, the old manor was renovated and a new wooden house was built nearby. In 1606 the plan of the manor and garden was prepared for the king by Alessandro Albertini. 

When in 1619 the king purchased the allotments belonging to Augustinian friars the construction of a new brick palace become possible. The spot for a Royal summer palace was chosen approximately 120 meters north from the original manor. According to the cornerstone found in 1972 in the foundations of the eastern wing the construction started on September 16, 1624. The structure was designed by Matteo Castelli and Constantino Tencalla and accomplished after king's death by his son Ladislaus IV Vasa. In 1655 during the so-called Deluge of the Polish-Lithuanian Commonwealth (invasion of allied forces of Sweden from north, Brandenburg from west, Transilvania from south and Muscovy from East), the castle was devastated and remained practically uninhabited till 1668 when it was given to Teodor Denhoff.

​It is a rectangular building with four octagonal towers at the corners, arcaded courtyard and a loggia with a view on Vistula River. Largely destroyed several times, it was reconstructed in 1975. 

Plan of the manor and garden in Ujazdów near Warsaw in 1606 by Alessandro Albertini, scale from. 1: 800, hand drawn multicolored document, 42 × 56 cm (16.5 × 22 in), signed:  Il sito della villa di Jasdovia; Alessandro Albertini, 1606, Archiwum Główne Akt Dawnych w Warszawie, Zb. Kart. 570 – 1.

Cornerstone of the Ujazdów Castle, sandstone, 57 × 57 × 10 cm (22.4 × 22.4 × 3.9 in), inscription in Latin: REGIAE AMOENITATI / SACRA / COELO SOLO LVCO LACV COLLE VALLE / LAETA / PALATIA AESTIVA / FELICIB[us]. FVNDAMENTIS AVSPICATVRV[m.] SAXVM / ANNO D[omi]NI MDCXXIV SEPTEMBR[e] / SIGISMVNDO III POLONIAE XXXVII / CO[n]STANCIA ANNO REGE / POSITVM / ANNO D[omi]NI 1624 DIE 7[septem]BRIS (Devoted Royal delight (...) summer palace), Muzeum Zamku i Szpitala Wojskowego na Ujazdowie​.